Discover Exclusive Offers and Special Deals on MSC Cruise Deals
Find a cruise and book cruises direct - no booking fee!
  1. Cruise Booking
  2. By Length
  3. 21 Night Cruises

21 Night Cruises

Cruises for 21 Nights

Find the best 21-night cruise on your budget and book your unforgettable vacation today. Here you will find amazing 21-nights cruise trips around the year. Discover a wide selection of itineraries, ships, and cruise lines for your 21-nights getaway. Whether you seek a family cruise or an adult-only retreat, book now on CruiseBooking.com for an unforgettable experience.

419 Itineraries Found
  • Filters:

21 Nights | Transatlantic | MSC Cruises | MSC Seaside

21 Nights | Transatlantic | MSC Cruises | MSC Seaside
MSC Cruises

MSC Seaside

Civitavecchia (Rome) Miami

21 Nights
Civitavecchia (Rome) | Palermo | Barcelona | Valencia | Cadiz | Santa Cruz de Tenerife | Barbados (Bridgetown) | St George's | San Juan | Miami **

Cruise Deals from Civitavecchia (Rome) to Miami

Lowest Rate*
  • Interior $709.00
  • Oceanview $949.00
  • Balcony $1,199.00
  • Suite $2,179.00
From $709.00* $33.76 / night(s)

21 Nights | Southern Europe | MSC Cruises | MSC Poesia

21 Nights | Southern Europe | MSC Cruises | MSC Poesia
MSC Cruises

MSC Poesia

Genoa Buenos Aires

21 Nights
Genoa | Marseille | Tarragona | Valencia | Cadiz | Lisbon | Las Palmas | Santa Cruz de Tenerife | Recife | Salvador | Rio De Janeiro | Buenos Aires **

Cruise Deals from Genoa to Buenos Aires

Lowest Rate*
  • Interior $739.00
  • Oceanview $1,019.00
  • Balcony $1,349.00
  • Suite $3,929.00
From $739.00* $35.19 / night(s)

21 Nights | Europe | MSC Cruises | MSC Grandiosa

21 Nights | Europe | MSC Cruises | MSC Grandiosa
MSC Cruises

MSC Grandiosa

Genoa Santos

21 Nights
Genoa | Marseille | Barcelona | Malaga | Funchal | Santa Cruz de Tenerife | Maceio | Salvador | Rio De Janeiro | Illhabela | Santos **

Cruise Deals from Genoa to Santos

Lowest Rate*
  • Interior $919.00
  • Oceanview $1,409.00
  • Balcony $1,899.00
  • Suite $4,959.00
From $919.00* $43.76 / night(s)

21 Nights | Southern Europe | MSC Cruises | MSC Grandiosa

21 Nights | Southern Europe | MSC Cruises | MSC Grandiosa
MSC Cruises

MSC Grandiosa

Rio De Janeiro Civitavecchia (Rome)

21 Nights
Rio De Janeiro | Buzios | Salvador | Maceio | Las Palmas | Arrecifes | TNG | Malaga | Valencia | Marseille | Genoa | Civitavecchia (Rome) **

Cruise Deals from Rio De Janeiro to Civitavecchia (Rome)

Lowest Rate*
  • Interior $1,059.00
  • Oceanview $1,549.00
  • Balcony $2,039.00
  • Suite $4,989.00
From $1,059.00* $50.43 / night(s)

21 Nights | Southern Europe | MSC Cruises | MSC Grandiosa

21 Nights | Southern Europe | MSC Cruises | MSC Grandiosa
MSC Cruises

MSC Grandiosa

Santos Genoa

21 Nights
Santos | Rio De Janeiro | Buzios | Salvador | Maceio | Las Palmas | Arrecifes | TNG | Malaga | Valencia | Marseille | Genoa **

Cruise Deals from Santos to Genoa

Lowest Rate*
  • Interior $1,059.00
  • Oceanview $1,549.00
  • Balcony $2,039.00
  • Suite $4,169.00
From $1,059.00* $50.43 / night(s)

FAQs for 21 Night Cruises

The cost of a 21-night cruise with a family can vary depending on various factors such as cruise line, destination, cabin type, and amenities. Prices can range from a few thousand dollars to several tens of thousands of dollars.

The benefits of doing a 21-nights cruise trip are extensive exploration, relaxation and entertainment, an all-inclusive experience, a family-friendly atmosphere, and unpack once and visit multiple destinations.

When it comes to destinations for a 21-night cruise, there are numerous options. However, one suggestion for an enjoyable 21-night cruise could be a Mediterranean itinerary. This region offers a diverse mix of historical sites, stunning landscapes, and vibrant cultures. You can visit iconic cities like Barcelona, Rome, Athens, and Istanbul, explore picturesque islands such as Santorini and Mykonos, and experience the charm of lesser-known ports. The Mediterranean provides a perfect blend of history, culture, and natural beauty that can make a 21-night cruise truly memorable.
Cruise Inquiry