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  1. Cruise Booking
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  3. Top 10 Sailings By Destinations
  4. South America
Top 10 Destinations

Top 10 Sailings to South America

Top 10 Destinations
All Alaska Bahamas Caribbean Caribbean Eastern Caribbean Southern Caribbean Western Europe Eastern Mediterranean Western Mediterranean Asia and Asia Pacific South America Northern Europe Southern Europe Western Europe Arabian Gulf

Some of the most breathtaking cruises in the world are cruises to South America. On this cruise, you find stops at interesting places in Brazil, Argentina, Chile, Uruguay, and more. Sail through lush green jungles or colorful towns or gaze at intoxicating fjords.This place could induce a thousand emotions-from the calm, peaceful looks of Patagonian towns whipped with the upbeat tempo of vibrant samba music in Rio. The ports tend to mix a dash of culture and history with amazing locales and drastically different cultures. Therefore, it is a perfect combination of nature, adventure, and experiences that could alter the world's view.

Book the Top 10 Sailing to South America

Grab your choice from one of the Top Ten South America sailing trips for the breathtaking views, unique culture, mouth-watering local cuisines, and everlasting memories.

MSC Preziosa
#1
South America | MSC Preziosa | 3 Nights
  • Dec 16, 2025   →   Dec 19, 2025
  • Santos ↻
$962.35* Starting From $532.35*
Includes taxes and fees*
South America
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South America
$962.35* Starting From $532.35*
Includes taxes and fees*
Book Now
Azamara Quest
#2
South America | Azamara Quest | 8 Nights
$5,169.00* Starting From $2,509.00*
Includes taxes and fees*
South America
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South America
$5,169.00* Starting From $2,509.00*
Includes taxes and fees*
Book Now
Azamara Quest
#3
South America | Azamara Quest | 13 Nights
$6,849.00* Starting From $3,659.00*
Includes taxes and fees*
South America
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South America
$6,849.00* Starting From $3,659.00*
Includes taxes and fees*
Book Now
Celebrity Equinox
#4
South America | Celebrity Equinox | 14 Nights
$7,834.48* Starting From $1,928.48*
Includes taxes and fees*
South America
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South America
$7,834.48* Starting From $1,928.48*
Includes taxes and fees*
Book Now
Celebrity Equinox
#5
South America | Celebrity Equinox | 14 Nights
$7,834.48* Starting From $1,928.48*
Includes taxes and fees*
South America
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South America
$7,834.48* Starting From $1,928.48*
Includes taxes and fees*
Book Now
Costa Diadema
#6
South America | Costa Diadema | 3 Nights
  • Apr 08, 2026   →   Apr 11, 2026
  • Itajai ↻
$770.00* Starting From $560.00*
Includes taxes and fees*
South America
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South America
$770.00* Starting From $560.00*
Includes taxes and fees*
Book Now
Costa Diadema
#7
South America | Costa Diadema | 3 Nights
  • Apr 01, 2026   →   Apr 04, 2026
  • Itajai ↻
$680.00* Starting From $500.00*
Includes taxes and fees*
South America
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South America
$680.00* Starting From $500.00*
Includes taxes and fees*
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Queen Anne
#8
South America | Queen Anne | 14 Nights
$5,919.00* Starting From $1,599.00*
Includes taxes and fees*
South America
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South America
$5,919.00* Starting From $1,599.00*
Includes taxes and fees*
Book Now
Queen Anne
#9
South America | Queen Anne | 33 Nights
$18,219.00* Starting From $5,699.00*
Includes taxes and fees*
South America
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South America
$18,219.00* Starting From $5,699.00*
Includes taxes and fees*
Book Now
Sapphire Princess
#10
South America | Sapphire Princess | 20 Nights
$2,998.00* Starting From $1,898.00*
Includes taxes and fees*
South America
Book Now
South America
$2,998.00* Starting From $1,898.00*
Includes taxes and fees*
Book Now

Top Reasons to choose a South America cruise with CruiseBooking.com

CruiseBooking.com makes the adventure of South America easy, exciting, and stress-free. Planning tools and loads of great offers make booking a wonderful cruise from wherever you are in the world a snap. Here are reasons why you should let us be of assistance booking that cruise for South America.

Weekly Cruise Specials

These fantastic weekly offerings are available for last-minute vacations or a cold one-at-good-price kind of cruise. Options are selected with the best itinerary in mind at attractive rates; thus, all offers are placed on one page for a quick comparison, able to be booked in seconds, with no unnecessary steps or long waiting time. Once you find a real deal like this, grab your cabin, and start packing.

One Tool to Keep Track of Prices

Enough guessing! Go for our 120-Day Tracking. Watch fares change over time and insist on the best price available. Early or late, a cruise will show you various trends, timely drop alerts, and pay less in the end.

Group Booking Made Simple

Traveling alongside friends or family? We do keep things simple in the field of group cruising. On your side, we do everything: from holding the cabins side-by-side for your group to making requests for shared discounts. Our staff offer flawless cruising from boarding your people to receiving them at home.

Scintillating cities

The city along the South American coast offers a life filled with culture-and the life-giving ocean with numerous beaches in Rio-or an old-world European ambience with Buenos Aires. Our cruise ports could be those laid-back streets of Montevideo, the ultramodern skyline of São Paulo, or quaint old-world glory in Quito before flying away to the Galapagos. Each shore is a recipe of a pinch of flavor, a little history, and lots of lively spirits!

FAQs About Top 10 Sailings of South America

A South American cruise has some cool towns, diverse scenery, and stops that provide ample time for leisure at every stop. Your itinerary will have a lot of cultural interaction, gorgeous days of cruising, and fun excursions ashore to visit splendid sites such as Rio de Janeiro, Buenos Aires, and the Chilean fjords.

The Cruise Lines include Princess, Holland America, MSC, and Celebrity in their great South America itineraries. These still offer itineraries demonstrating the absolute best one could imagine along with comfort, fine food, and shore excursions with high educational values.

The safer months are those between November and March, chiefly the southern ones of Patagonia. During this period, water is calm and weather conditions satisfying. Excursions on the Amazon River can sail all year round, as each season would be nice in its own.

If sightseeing options are to be considered, comfortable walking shoes are a must. While swimsuits and light clothing would suffice for a warm-weather break, perhaps something light would best do for the tropics. Pack away some warm clothes when it gets cold and windy in the south, along with a waterproof jacket.
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