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2025 Cruise Sailings to Santiago from Cape Town

Santiago Cruises from Cape Town in 2025

Embark on an unforgettable cruise from Cape Town to Santiago in 2025.

122 Itineraries Found

*All prices are per person, in US Dollars, based on double occupancy.

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3 Nights | Indian Ocean | MSC Cruises | MSC Armonia

3 Nights | Indian Ocean | MSC Cruises | MSC Armonia

MSC Armonia virtual-360

Cape Town Durban

3 Nights

Cape Town | Durban **

Cruise Deals from Cape Town to Durban

Lowest Rate*
  • Interior $347.69*
  • Oceanview $400.69*
  • Balcony $505.69*
  • Suite $664.69*
From USD $347.69* USD $115.90* / night(s) Includes taxes and fees*

3 Nights | Indian Ocean | MSC Cruises | MSC Armonia

3 Nights | Indian Ocean | MSC Cruises | MSC Armonia
Lowest Rate*
  • Interior $439.69*
  • Oceanview $492.69*
  • Balcony $624.69*
  • Suite $756.69*
From USD $439.69* USD $146.56* / night(s) Includes taxes and fees*

5 Nights | Indian Ocean | MSC Cruises | MSC Armonia

5 Nights | Indian Ocean | MSC Cruises | MSC Armonia
Lowest Rate*
  • Interior $730.35*
  • Oceanview $862.35*
  • Balcony $1,060.35*
  • Suite $1,258.35*
From USD $730.35* USD $146.07* / night(s) Includes taxes and fees*

16 Nights | Middle East | Costa Cruises | Costa Smeralda

16 Nights | Middle East | Costa Cruises | Costa Smeralda

Costa Smeralda virtual-360

Cape Town Dubai

16 Nights

Cape Town | Port Elizabeth | Port Louis | Muscat | Dubai **

Cruise Deals from Cape Town to Dubai

Lowest Rate*
  • Interior $1,295.90*
  • Oceanview $1,495.90*
  • Balcony $1,635.90*
From USD $1,295.90* USD $80.99* / night(s) Includes taxes and fees*

18 Nights | Southern Europe | Costa Cruises | Costa Smeralda

18 Nights | Southern Europe | Costa Cruises | Costa Smeralda

Costa Smeralda virtual-360

Cape Town Barcelona

18 Nights

Cape Town | Walvis Bay | Santa Cruz de Tenerife | TNG | Barcelona **

Cruise Deals from Cape Town to Barcelona

Lowest Rate*
  • Interior $1,609.59*
  • Oceanview $1,889.59*
  • Balcony $2,069.59*
From USD $1,609.59* USD $89.42* / night(s) Includes taxes and fees*

This adventure promises stunning landscapes, fascinating cultures, and exciting activities as you travel from Africa to South America. Begin your journey in Cape Town, known for its breathtaking views from Table Mountain. Then, sail across the Atlantic, exploring exotic ports, savoring diverse cuisine, and enjoying onboard entertainment. Arriving in Santiago, immerse yourself in Chile's rich heritage, vibrant cities, and world-famous wine regions, making this cruise a unique and memorable experience.

FAMOUS PORTS OF CALL TO SANTIAGO FROM CAPE TOWN 

Embark on a remarkable cruise from Cape Town to Santiago in 2025, traversing diverse and intriguing destinations along the Atlantic and South American coasts. From exploring historic towns to enjoying scenic landscapes and vibrant cultures, each port provides its own unique charm.

Lüderitz

Nestled on Namibia's southwestern coast, Lüderitz boasts German colonial architecture and stunning coastal scenery. Visitors can explore the abandoned diamond mining town of Kolmanskop or take a scenic boat tour of Lüderitz Bay.

Walvis Bay

A thriving port in Namibia, Walvis Bay is known for its dramatic sand dunes, rich wildlife, and picturesque lagoon. Take a boat tour to see flamingos, dolphins, and seals, or visit the famous Dune 7 for sandboarding.

Jamestown

Located on the remote island of Saint Helena, Jamestown is a quaint, historic town with colorful Georgian architecture. Explore the island's volcanic landscapes, visit Napoleon's exile home, or climb the famous Jacob’s Ladder.

Rio de Janeiro

Brazil's vibrant city offers iconic landmarks like Christ the Redeemer and Sugarloaf Mountain. Unwind on Copacabana Beach, explore the colonial architecture of Santa Teresa, or immerse yourself in the city's lively samba culture.

Santos

Santos, the busiest port in Brazil, is famous for its long beachfront gardens and coffee history. Visit the Coffee Museum, explore the old town, or take a stroll through the Orquidário botanical garden.

Itajaí

A charming coastal city in southern Brazil, Itajaí is known for its beautiful beaches and seafood cuisine. Explore the local markets, relax on Praia Brava, or visit nearby Blumenau, a city with strong German roots.

Port Stanley

As the capital of the Falkland Islands, Port Stanley features British charm and unique wildlife. Visit the Whalebone Arch, spot penguins along the coastline, or learn about the islands' history at the Falkland Islands Museum.

Buenos Aires

Argentina's capital blends European elegance and Latin spirit. Wander the colorful streets of La Boca, enjoy a tango show, or visit the historic landmarks of Plaza de Mayo and Recoleta Cemetery.

Other Cruises Destinations from Cape Town:

FAQS FOR CRUISES TO SANTIAGO FROM CAPE TOWN IN 2025

  • Entertainment: Watch live music, theatrical shows, and themed parties.
  • Dining: Savor a mix of international cuisine and regional specialties.
  • Relaxation: Unwind at the spa or by the pool.
  • Workshops: Learn through enrichment lectures, dance classes, or cooking demos.

  • Table Mountain: Start the journey with breathtaking views from Cape Town’s iconic mountain. 
  • Valparaíso: Explore the colorful hillside city and its funiculars. 
  • Santiago: Visit the city's museums, Cerro San Cristóbal and Plaza de Armas. 
  • Chilean Wine Regions: Taste local wines in renowned vineyards near Santiago.

Check travel documents and health requirements, plan your excursions early, and bring enough layers for varied weather conditions.

  • City Tours: Learn about Santiago's culture, history, and architecture. 
  • Outdoor Adventures: Go hiking, biking, or wildlife spotting. 
  • Wine Tours: Visit vineyards and taste Chilean wines. 
  • Cultural Experiences: Attend traditional dance shows and visit local markets.

From October to March, during the Southern Hemisphere's summer, for the best weather and a lively atmosphere.

  • Clothing: Light, breathable clothing for warm days, and jackets for cooler evenings. 
  • Footwear: Comfortable walking shoes and sandals. 
  • Sun Protection: Sunglasses, sunscreen, and a hat. 
  • Travel Documents: Passport, visa (if required), and insurance. 
  • Personal Essentials: Toiletries, medications, and a camera.