2025 Cruise Sailings to Miami from Los Angeles

These voyages will take you across the Panama Canal, and you’ll get to see so many different landscapes, from the sun-drenched beaches of Southern California to the vibrant city life of Miami. As the cruise lines add more ships, more amenities, and more curated shore excursions, you’ll get to relax, explore, and cross two oceans.

FAMOUS PORTS OF CALL TO MIAMI FROM LOS ANGELES

Cruises from LA to Miami travel the Pacific and Caribbean and stop at many exciting ports along the way. These ports of call offer a mix of culture, history, and nature, so the journey from LA to Miami will be varied and interesting. In 2025, these cruises may include:

Los Cabos

Los Cabos is at the southernmost tip of the Baja California Peninsula and is all about natural beauty and local culture. Cruise passengers can visit the famous Arch of Cabo San Lucas, the rock formation at Land’s End, or relax on the beach. The area is also known for its nightlife, luxury resorts, and water activities like snorkeling and whale watching. Whether you want adventure or relaxation, Los Cabos has it all, with a mix of nature and modern amenities.

Puerto Vallarta

Puerto Vallarta is a charming city on Mexico’s Pacific coast with cobblestone streets, colonial architecture, and an art scene. Cruisers can walk the Malecón boardwalk and enjoy the ocean views and sculptures. Mountains surround the city, which is perfect for eco-tours and zip-lining. Puerto Vallarta is also famous for its food scene, with many restaurants serving traditional Mexican and international cuisine, so it’s a must-visit for foodies.

Acapulco

Acapulco was the playground of the Hollywood stars and is famous for its beaches and cliffs. A must-see is the cliff diving show at La Quebrada, where divers jump from 130 feet into the Pacific Ocean. The city’s history is also on display at the San Diego Fort, where you can learn about Acapulco’s colonial past. You can relax on the beautiful beaches of Playa Condesa or enjoy the nightlife. Acapulco has natural beauty and a rich cultural heritage. 

Puerto Quetzal

Puerto Quetzal is Guatemala’s main Pacific port and the doorway to all the country’s cultural and natural wonders. The port itself is industrial, but it gives you access to historic Antigua, a UNESCO World Heritage site with beautifully preserved Spanish Baroque architecture and exciting festivals. Nature lovers can visit the nearby coffee plantations or Lake Atitlán, surrounded by volcanoes and indigenous villages. Puerto Quetzal is the starting point for many excursions that showcase Guatemala’s cultural and natural diversity.

Panama City

Panama City is the capital of Panama and a bustling metropolis where modern skyscrapers meet historic Casco Viejo, a UNESCO World Heritage site. Visitors can visit the Panama Canal, one of the world’s most impressive man-made wonders, and get up close to massive ships passing through the locks. The city also has a vibrant cultural scene with museums, theaters, and restaurants serving many cuisines. For nature lovers, the nearby rainforests and Amador Causeway are great for hiking and birdwatching, making Panama City a city that has it all.

Cartagena

Cartagena, Colombia, is a coastal city with a rich history, famous for its colonial architecture and Caribbean culture. The Old Town, a UNESCO World Heritage site, is surrounded by ancient walls and filled with colorful buildings, cobblestone streets, and charming plazas. Visitors can visit the Castillo San Felipe de Barajas, the massive fortress that towers over the city. Cartagena’s street life, beaches, and history make it a must-see, a mix of culture and relaxation.

George Town, Grand Cayman Island

George Town is the capital of the Cayman Islands and a cruise ship favorite. It is famous for its beaches, clear waters, and world-class diving. Seven Mile Beach is consistently voted one of the best in the world. It has soft white sand and turquoise waters that are perfect for swimming and sunbathing. The Cayman Turtle Centre is where you can learn about and interact with sea turtles. George Town’s duty-free shopping, coral reefs, and the unique experience of Stingray City, where you can swim with stingrays make it a must-see.

Manzanillo

Manzanillo is on Mexico’s Pacific coast and is famous for its beaches and maritime history. It’s often called the “Sailfish Capital of the World,” so it’s a must-see for sport fishermen. The twin bays, Bahía de Manzanillo and Bahía de Santiago offer great water sports, snorkeling, and scuba diving. Visitors can also explore the historic downtown area with its colonial architecture or relax on Playa La Audiencia, a sheltered beach perfect for swimming.

Other Cruises Destinations from Los Angeles: