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Cruises for 21-nights

21 Night Cruises

These hand-picked 21-night cruises run all year round, an alluring combination of wonderful locations, excellent ships, and top-class cruise lines. Whatever your criteria aremaybe an adults-only party or awild family getaway or even a cultural exploration of continents-a long-distance getaway will be perfect for you. CruiseBooking.com is the place to begin your search, planning, and booking for that three-week cruise voyage that will be etched into memory forever.

603 Itineraries Found

*All prices are per person, in US Dollars, based on double occupancy.

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21 Nights | Transatlantic | MSC Cruises | MSC Grandiosa

21 Nights | Transatlantic | MSC Cruises | MSC Grandiosa

MSC Grandiosa virtual-360

Orlando (Port Canaveral) Barcelona

21 Nights

Orlando (Port Canaveral) | Nassau | Ocean Cay | POP | Orlando (Port Canaveral) | Miami | St Maarten (Philipsburg) | Funchal | Barcelona **

Cruise Deals from Orlando (Port Canaveral) to Barcelona

Lowest Rate*
  • Interior $1,348.92*
  • Oceanview $1,648.92*
  • Balcony $1,938.92*
From USD $1,348.92* USD $64.23* / night(s) Includes taxes and fees*

21 Nights | Transatlantic | MSC Cruises | MSC Divina

21 Nights | Transatlantic | MSC Cruises | MSC Divina

MSC Divina virtual-360

Naples Miami

21 Nights

Naples | Rome (Civitavecchia) | Genoa | Marseille | Barcelona | Valencia | Alicante | Lisbon | Funchal | St. Johns | St Maarten (Philipsburg) | San Juan | Miami **

Cruise Deals from Naples to Miami

Lowest Rate*
  • Interior $1,358.92*
From USD $1,358.92* USD $64.71* / night(s) Includes taxes and fees*

21 Nights | Caribbean | MSC Cruises | MSC Seaview

21 Nights | Caribbean | MSC Cruises | MSC Seaview

MSC Seaview virtual-360

Genoa Fort de France

21 Nights

Genoa | Rome (Civitavecchia) | AJAC | Marseille | Barcelona | Las Palmas | St Maarten (Philipsburg) | Basseterre | Roseau | Bridgetown | St George's | KGTN | Fort de France **

Cruise Deals from Genoa to Fort de France

Lowest Rate*
  • Interior $1,392.92*
  • Oceanview $1,662.92*
  • Balcony $1,922.92*
  • Suite $3,552.92*
From USD $1,392.92* USD $66.33* / night(s) Includes taxes and fees*

21 Nights | Caribbean | Holland America | Zuiderdam

21 Nights | Caribbean | Holland America | Zuiderdam

Zuiderdam

Boston Miami

21 Nights

Boston | San Juan | St Thomas | St Maarten (Philipsburg) | Castries | Bridgetown | Willemstad | HAFC | Miami | Grand Turk | San Juan | St Thomas | HAFC | Miami **

Cruise Deals from Boston to Miami

Lowest Rate*
  • Interior $1,498.00*
  • Oceanview $1,499.00*
  • Balcony $1,899.00*
  • Suite $2,999.00*
From USD $1,498.00* USD $71.33* / night(s) Includes taxes and fees*

21 Nights | Caribbean | Holland America | Rotterdam

21 Nights | Caribbean | Holland America | Rotterdam

Rotterdam

Ft Lauderdale (Port Everglades)

21 Nights

Ft Lauderdale (Port Everglades) | HAFC | Willemstad | Cartagena | Cristóbal | Panama Canal | Gatun Lake | Cristóbal | Colon | Limon (Puerto Limon) | George Town | Ft Lauderdale (Port Everglades) | Willemstad | KRLD | Oranjestad | HAFC | Ft Lauderdale (Port Everglades) **

Cruise Deals from Ft Lauderdale (Port Everglades)

Lowest Rate*
  • Interior $1,569.00*
  • Oceanview $2,229.00*
  • Balcony $2,679.00*
From USD $1,569.00* USD $74.71* / night(s) Includes taxes and fees*

Types of 21-Night Cruises on CruiseBooking.com

1. 21-Night Transatlantic Cruise

21-Night Transatlantic Cruise
Photo Courtesy: Holland America Line

Ideal For: Slow travelers and beachgoers.

Overview: They offer the perfect opportunity to experience a few days in blue waters or enjoy a private walk.

Some choices of cruise lines are:

  • Holland America Line: Cultural excursions and onboard enrichment.
  • Cunard: Traditional luxury cruises with a British touch.
  • MSC Cruises: More budget options with a huge number of itineraries.

2. The Grand Mediterranean 21-Night Cruise

The Grand Mediterranean 21-Night Cruise
Photo Courtesy: Celebrity Cruises

Ideal For: Artists, gastronomy, and history

Overview: The cruise features the usual Southern European immersion stage of Italy, Greece, France, Spain, Malta, and Turkey. Taste Mediterranean flavors, historical cities, and UNESCO sites.

Cruise Lines to Consider:

  • Celebrity Cruises: An entertainer with an opportunity for glamour, and all excursions are well planned.
  • Princess: Offers well-rounded itineraries and first-rate service.
  • Costa Cruises: Offers Mediterranean cruises that are outright deeply into culture.

3. Repositioning 21-Night Cruises

Repositioning 21-Night Cruises
Photo Courtesy: Royal Caribbean

Ideal For: Seasoned travelers, and thrill seekers

Overview: During the changes in seasons, like from the Caribbean to Europe, these one-way cruises reposition ships from one location to the other. A huge variety of ports and certain sea days allows one to possibly pay less.

Consider cruise lines like:

  • Norwegian Cruise Line: Unusual routes and diversity of onboard activities.
  • Royal Caribbean: Seasonal moves with full-facility ship.
  • Oceania Cruises: Fine service with distant locales.

4. 21-night segments of a world cruise

21-night segments of a world cruise
Photo Courtesy: Seabourn

Ideal For: Culture buffs, and retirees.

Overview: You get an ocean-liner-like flavor of a world cruise for 21 nights with shore excursions that really excite the senses, wonderful, specialized programs on board, and usually cover areas like Asia, South America, or the Middle East.

Cruise Lines to Consider:

  • Seabourn: Luxurious sailing and all-inclusive facilities.
  • Viking Ocean Cruises: Small-ship elegance with a destination focus.
  • Holland America Line: Magnificent transcontinental journeys

5. South Pacific and Hawaii-21-night cruises

South Pacific and Hawaii-21-night cruises
Photo Courtesy: Princess

Ideal For: The ones for sun worshippers, island explorers, and nature enthusiasts.

Overview: Expect the scenery to be breathtaking, and at ease with just a sprinkle of cultural delight.

Cruise lines explorations:

  • Princess Cruises: Take the Princess Cruises for Hawaiian cruising from California or Australia.
  • Carnival Cruises: For a fun-filled itinerary to tropical shores.
  • P&O Cruises: Australia for South Pacific sailing with a regional twist.

6. Northern and Western Europe-21-night cruises

Northern and Western Europe-21-night cruises
Photo Courtesy: Azamara

Ideal For: For those who breathe history, culture, and chilly weather.

Overview: The trips center around natural scenery, enchanting ancient cities, and historical places.

The cruise lines to Consider:

  • Azamara: Small ships with destination focus.
  • MSC Cruises: Multilingual and European-value service.
  • Princess Cruises: All-inclusive European package with expert local guides.

Popular Destinations for 21-Night Cruises

Region Departure Ports Destinations Covered Highlights
Transatlantic Miami, New York, Barcelona, Southampton Spain, Portugal, Canary Islands, Caribbean, U.S. East Coast Spectacular ocean crossings backed by cultural cities to specially arrange leisure days at sea
Caribbean Fort Lauderdale, Miami, San Juan Eastern, Western & Southern Caribbean, ABC Islands, Panama Canal Water sports, medieval forts, tropical beaches, and island hopping
World Cruise Sydney, Miami, Los Angeles, Southampton Multiple continents—Asia, Europe, Americas, Oceania, Africa Going around the world, reaching dream spots, and spending the nights at the port
Southern Europe Barcelona, Rome (Civitavecchia), Athens Italy, Greece, Turkey, Croatia, France Mediterranean food, picturesque coasts, and ancient ruins
Europe Amsterdam, Southampton, Copenhagen UK, Norway, Iceland, the Baltics, Western Europe Historic towns, fjords, castles, and natural wonders
Hawaii Los Angeles, San Francisco, Vancouver Oahu, Maui, Kauai, Big Island + West Coast USA or South Pacific Beach, waterfalls, Polynesian culture, and volcanism
North America New York, Seattle, Vancouver, Montreal Alaska, Canada/New England, Pacific Coast, U.S. Gulf & Atlantic cities Glaciers, animals, autumn color, and quaint seaside villages
Bermuda Boston, New York, Baltimore Bermuda + Caribbean or Eastern U.S. Colonial villages, coral pink beaches, golf, and snorkeling
Mediterranean Rome, Athens, Barcelona, Venice Italy, Greece, France, Spain, Malta, Turkey UNESCO landmarks, local markets, deep history, and gastronomic delights

What to Expect on a 21-Night Cruise

Every 21-night cruise needs to be in equal parts exciting adventure, glamor, and relaxation, with plenty of opportunities for adventure. Some of what goes into this three-week sea voyage includes:

  • Various International Itineraries: Passing across continents and regions, may include stops in famous cities, isolated islands, and cultural hubs.
  • Wellness & Spa: Offer wellness for all, from massages, yoga, and relaxation techniques in adult-only areas, to recovery treatments on the sandy beach.
  • More Onboard Entertainment: Cultural workshops, enrichment talks, themed night events, guest stars, and rotating shows.
  • Dining: A different flavor is served each day, many for free with the cruise price, although some extras are charged. Buffet-style dining to gourmet open-choice dining.

What to Expect on a 2-Night Cruise?

  • Onboard Dining & Buffets: Enjoy a variety of cuisines, late-night snacks, and specialty dining (extra charge).
  • Live Shows & Entertainment: Broadway-style performances, comedy acts, karaoke nights, and deck parties.
  • Pool, Spa, and Bars: Relax by the pool, book a spa session, or sip cocktails at the sunset bar.
  • Shore Excursion (Optional, 1-day, or half-day): Explore one port destination with optional guided tours, beach trips, or cultural walks.

Pros & Cons of 21-Night Cruises

Pros Cons
Multiple nations are visited in one trip Higher upfront price than the shorter cruises.
Unpack once and relax Greater time commitment (3+ weeks).
Nice time for port visits and plenty of Rest and Relaxation May feel a little bit claustrophobic in cabin space after some time.
Complete cultural immersion Weariness from travel may affect some passengers.
Many enrichment and entertainment activities on board Not much flexibility in the itinerary; must adhere to the entire schedule.
Develop mutually beneficial and lasting bonds with fellow cruise bus passengers It is very difficult to accommodate different seasons.

Tips for Booking a 21-Night Cruise

  • Booking early is key to finding the best accommodations and cabin locations. Early bird fare, together with other benefits worth cherishing, such as onboard credit, are among the examples.
  • An excellent cozy cabin with a big balcony is the ideal option since you will be on this cruise for three weeks.
  • Confirm all passport and visa formalities in every country you will be in; some may require pre-application.
  • Consider tips, excursion costs, Wi-Fi, and specialty dining for your budget.
  • A long trip usually crosses a lot of weather zones; therefore, pack for various situations.

FAQs for 21-Night Cruises

A 21-night cruise costs anywhere from $1,392* to $82,949* per person.

Yes, 21-night cruises delight in relaxation, thorough immersion, and a slower pace than shorter cruises.

Families should pick family-friendly vessels, plan for work and school, create packing lists for the kids, choose the best accommodations, keep in touch and remain safe, and strictly focus on having a good time with kid's club & babysitting facilities.

Think about such names as Princess Cruises, Holland America, Costa, and MSC.

Yes, that person would need to carry his/her passports on any 21-night cruise.

Prepare for a wardrobe that goes through many occasions, walking shoes, formal dresses, gym/sportswear, swimsuits, and odds and ends like petite bags for carrying around during shore excursions.

This will depend on the cruise line you book and the cruise fare. Typically, a 21-night cruise only includes base drinks such as those listed above, which are coffee, tea, juice, and tap water.

Yes, certainly. Shore visits are allowed during port stops.

Yes, travel insurance should be considered.

Many companies add gratuities automatically to one's account, or they can be prepaid prior to departure. Some cruise lines, like Silversea and Regent, may include gratuities in the cruise fare.

Yes, you can bring some pre-packed snacks.